Accession Number:

AD0652674

Title:

EXPERIENCE ON MASS VACCINATION OF HUMANS WITH LIVE COMBINED TYPHUS FEVER VACCINE FROM THE 'E' STRAIN OF RICKETTSIA PROWAZEKI,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1966-07-01

Pagination or Media Count:

11.0

Abstract:

In the test of the mass vaccination of persons with the live combined typhus vaccine E 1610 persons 2.6 of those inoculated displayed late reactions. The reactogenicity of young persons 18--25 years old to inoculation with ZhKSV-E in comparison with ZhSV-E was 3 times lower correspondingly 3.7 and 12.2. The degree of expression of late reactions in persons inoculated with combined vaccine E in relation to the entire number inoculated was as follows In 0.4 of those inoculated the late reactions proceeded without an increase of temperature, in 1.1 - with a subfebrile temperature, in 1 of those inoculated late reactions of moderate severity were observed, and in 0.12 - strong reactions. The duration of the manifestation of late reactions was as follows In 0.56 of the inoculated persons the late reactions lasted one day, in 1 of those inoculated - 2 days, in 0.62 - 3 days, and in 0.37 - 4 days. There were no late reactions lasting more than 5 days. The reactogenicity late of prepared combined typhus vaccine E does not differ from such a combined typhus vaccine prepared ex tempore prior to the inoculations. Based on the RSK, in the test on the vaccination of persons with the ZhKSV-E a good immunogenicity for the vaccine was revealed in 98. Based on the antibody titers in the RSK the effectiveness of combined vaccine was 2 times higher in comparison with the effectiveness of noncombined typhus vaccine E. Author

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE