CONCERNING OXYGEN DEFICIENCY DURING EXPERIMENTAL PLAGUE INFECTION
ARMY BIOLOGICAL LABS FREDERICK MD
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During experimental plague infection in guinea pigs, an oxygen deficiency was observed after one day. In the arterial and venous blood of guinea pigs infected with B. pestis the content of oxygen lowered significantly with the course of the experimental plague process. The oxygen capacity of the blood was reduced along with a simultaneous increase in the content of hemoglobin, which indicates a change in the biological properties of hemoglobin as an oxygen carrier. The oxygen deficiency which developed in guinea pigs during the process of plague infection cannot be confined to the framework of one type of hypoxia and includes elements of hypoxic, anemic and circulatory hypoxia.
- Medicine and Medical Research