Accession Number:

AD0651273

Title:

PROLONGATION OF ALLOGRAFT SURVIVAL BY AN ALPHAGLOBULIN ISOLATED FROM NORMAL BLOOD,

Descriptive Note:

Corporate Author:

BOSTON UNIV MASS SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1967-01-01

Pagination or Media Count:

17.0

Abstract:

A protein fraction with ability to inhibit the transplantation immune response has been isolated from normal human plasma by column chromatography, using methods similar to those previously described by Mowbray. Transplantation 115, 1963 In the present experiments the active material was eluted from the column by less concentrated buffer than that employed by Mowbray. The active fraction appeared to consist largely of alphaglobulin as determined by electrophoresis. A single 100 mg. dose of the active alphaglobulin administered intravenously induced a significant p 0.01 prolongation of survival up to 33 days of skin allografts in rabbits. A single intravenous infusion of 5 mg. of the alphaglobulin induced a significant p 0.001 prolongation of survival up to 20 days of C57 BL skin allografts in C3H mice. The alphaglobulin appeared to be entirely nontoxic in both species in the doses employed. Author

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE