Accession Number:

AD0650894

Title:

AN EXPERIMENTAL STUDY OF SIMULTANEOUS VACCINATION AGAINST TULAREMIA AND TUBERCULOSIS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1966-05-01

Pagination or Media Count:

8.0

Abstract:

The simultaneous cutaneous vaccination separately or associated against tularemia and tuberculosis creates a high immunity in guinea pigs against tularemia, and a specific resistance to subcutaneous infection with 1000 lethal doses of a virulent strain. Distinct immunological indices allergic reaction and agglutination in respect to tularemia were also noted in these pigs. In the animals which were inoculated simultaneous with the two vaccines, the local and general reactions were practically no different from the reactions in pigs which were inoculated with monovaccines. This demonstrates the harmlessness of combined vaccination. In guinea pigs which were vaccinated against tularemia and tuberculosis the immunity against tularemia was maintained over a period of 6 months period of observation to the same degree as in pigs which were inoculated with tularemia vaccine alone. The data obtained demonstrates the feasibility of the simultaneous vaccination against these two infections with the complete compatibility of the vaccines and a mild reactogenicity, which makes it possible to recommend that the appropriate testing of vaccination against tularemia and tuberculosis be carried out on humans.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE