EFFECT OF ADRENALECTOMY ON THE LIPID METABOLISM OF RATS WITH ACUTE INSULIN DEFICIENCY.
Annual rept. no. 1, Jun 65-Aug 66,
SAO PAULO UNIV (BRAZIL) SCHOOL OF MEDICINE OF RIBEIRAO PRETO
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The report investigates the effect of adrenalectomy on the plasma free fatty acids levels and on the adipose tissue and liver lipogenesis of rats with acute insulin deficiency. Parameters were measured 4, 10, and 24 hours after insulin withdrawal in alloxan diabetic rats previously treated with the hormone for at least 15 days. Adrenalectomy, or sham-operation in the controls, was performed 2 hours after the last injection of insulin. The lipogenetic activity was assessed by the rate of incorporation of 1-14C acetate into tissue fatty acids in vitro. Results 1 Adrenalectomy markedly reduced the increase of plasma FFA levels following insulin deprivation. 2 Adrenalectomy prevented inhibition of lipogenetic activity of adipose tissue of insulin deficient rats during the whole period of observation. 3 A similar effect, but less intense and of shorter duration, was observed in the liver. Author
- Medicine and Medical Research