Accession Number:

AD0648966

Title:

LIVER FUNCTION AND REGENERATION IN RATS X IRRADIATED AT BIRTH,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Report Date:

1967-02-08

Pagination or Media Count:

28.0

Abstract:

Radiation injury to the liver, an organ considered to be radioresistant, can be demonstrated by stimulating cell division through partial hepatectomy of hepatotoxic agents. The mitotic figures resulting from this induced cell proliferation are for the most part abnormal and apparently persist undiminished in numbers for long periods of time, even after several induced mitotic cycles. In the present investigation, animals subjected to X-irradiation 200 rad at one day of age have been studied 90 days later with respect to incidence of mitotic abnormalities in parenchymal cells after partial hepatectomy and to the functional competence of the liver. X-irradiation of neonatal rats results in a similar decrease in both liver and body weights of animals 90 days later. Thus, liver to body weight ratios for both irradiated and non-irradiated controls are the same. The regenerative capacity of the irradiated animals, i.e., the ability to replace hepatic mass as a result of partial hepatectomy, does not appear to be impaired. The incidence of abnormal mitoses approx. 45 of total anaphases and telophases is approximately 3-4 times greater than that of controls. In contrast, bile flow and BSP excretion rate are not affected in animals irradiated at one day of age. Therefore, the functional tests of bile flow and BSP excretion rate do not reflect the extensive nuclear damage present in parenchymal cells. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE