Accession Number:

AD0648616

Title:

PATHOLOGICAL CHANGES IN ABDOMINAL SYMPATHETIC GANGLIA OF ANIMALS WITH FULMINATING EXPERIMENTAL DIARRHEA

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s):

Report Date:

1965-05-10

Pagination or Media Count:

10.0

Abstract:

The abdominal vegetative nervous system was studied in Walter Reed strain guinea pigs with experimental diarrhea produced by the method of Kalas. During the diarrheal phase, the regional abdominal sympathetic ganglia are normal, but after approximately 72 hr. changes which we interpret as central chromatolysis take place in the ganglion cells. The latter remain uniformly and severely swollen for 10--18 days, when chronic changes and eventually cell death can be seen in occasional neurons. Most of the sympathetic nerve cells, however, have recovered by the 20th day, leaving a few pyknotic neurons behind in the ganglion. We conclude that local ischemia within the bowel wall, during the severe propulsive diarrhea, is responsible for damage to intramural nerves and the subsequent ascending axonal reaction. The significance of these findings is discussed.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE