A MODIFICATION OF CHICK EMBRYO RESISTANCE TO VARIOUS INFECTIONS UNDER THE EFFECT OF POLYSACCHARIDES ISOLATED FROM NONPATHOGENIC MICROBES
ARMY BIOLOGICAL LABS FREDERICK MD
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Biologically active polysaccharides from nonpathogenic microorganisms -- acetoxan, prodigiosin and glucose -- are capable of stimulating the nonspecific resistance of embryos to certain infections. In the early stages of development the chick embryos did not react to the administration of biologically active polysaccharides with a sufficient increase of resistance to a number of bacterial infections. As a measure of the development of the embryos, this capability was intensified and was well expressed and comparatively stable in 13-day embryos, and in 15-day embryos it reached a still higher level. At this age the administration of polysaccharides changed the development of infection in the embryos not only when they were administered prophylactically, but also when administered simultaneously with infection or following infection. Additional investigations are required for clearing up this peculiarity.