AN EXPERIMENTAL STUDY OF ENTERAL IMMUNIZATION WITH LIVE VACCINE AGAINST Q-FEVER
ARMY BIOLOGICAL DEFENSE RESEARCH CENTER FREDERICK MD
Pagination or Media Count:
The high susceptibility of guinea pigs to the enteral administration of vaccine strain M of Rickettsia burneti was established. The enteral administration of 60 ED50 intraperitoneal of vaccine strain M ensured the immunization of 50 of the guinea pigs. In the serum of guinea pigs, by the 20- -30th day following enteral immunization of 10 to the 4th power ED50 and by the 10--20th day when using 10 to the 6th power ED50 of strain M, complement-fixing antibodies appeared to the 2nd phase component of Rickettsia burneti. Guinea pigs, in whose serum complement-fixing antibodies were contained on the 20--30th day following enteral immunization, were non-susceptible to 10 to the 5th power ED50 of a virulent culture of Rickettsia burneti after 60--90 days. It is expedient to study the effectiveness of enteral immunization of persons against Q-fever with preparations of live vaccine of Rickettsia burneti strain M.
- Medicine and Medical Research