HYPOTHERMIA AND BLOOD FLOW THROUGH SKELETAL MUSCLE.
Rept. for 1 Sep 58-31 Aug 65,
NORTH CAROLINA UNIV CHAPEL HILL DEPT OF PHYSIOLOGY
Pagination or Media Count:
The effect of hypothermia on the circulation of skeletal muscle was studied. All experiments utilized the gracilis muscle of the dog. The rate of production of hypothermia determines the vascular response, a fast rate 1Cmin causing vasodilatation and a slow rate 1Cmin causing vasoconstriction. The oxygen uptake is decreased by temperature but is independent of the rate of production of hypothermia. The vascular response is well correlated with the pO2 of the venous blood determined from the oxygen dissociation curve whether the temperature is lowered rapidly or slowly. This suggests either a direct or indirect relationship between aerobic metabolism and vasomotor activity. The reactivity of the blood vessel, as indicated by reactive hyperemia, decreased during hypothermia but the rate of recovery of reactive hyperemia is independent of the temperature change and dependent on the rate of temperature change. This means that the time for recovery from reactive hyperemia is determined by the effect of hypothermia on the control blood flow. Author
- Anatomy and Physiology