Accession Number:

AD0647173

Title:

STUDIES ON LEPTOSPIROSIS IN THAILAND, WITH SPECIAL REFERENCE TO THE EPIDEMIOLOGY, PATHOLOGY AND CLINICAL ASPECTS, AND ITS RELATION TO THE ANIMAL RESERVOIR HOSTS.

Descriptive Note:

Progress rept. no. 2, 1 Sep 65-31 Dec 66 (Final),

Corporate Author:

UNIVERSITY OF MEDICAL SCIENCES BANGKOK (THAILAND) BANGKOK SCHOOL OF TROPICAL MEDICINE

Personal Author(s):

Report Date:

1966-12-31

Pagination or Media Count:

54.0

Abstract:

Epidemiological study revealed prevalence of human leptospirosis in Thailand, incidence of 7-24 common serotypes were L. akiyami A, L. icterohemorrhagiae, L. bataviae and L. australis, in the provincial areas and L. bataviae in Bangkok. Studies on 17 non-fatal cases revealed moderate degree of histopathological changes of the liver with no serious impairment of liver functions, which had no correlation with rising antibody titres. Canine leptospirosis was less in house dogs than stray dogs, both being higher in late rainy season and early winter than in summer. L. bataviae was the most common serotype found in Rattus norvegicus obtained from four municipalities of East Thailand. Field and forest rats harboured infection at a lower rate and exhibited more serotypes Semi-annual Report. In Northeast Thailand, the highest rate was found at Khon Khaen, and L. javanica was most common in Rattus rattus. Canine leptospirosis was low. Pathological changes in the kidneys of hamsters infected with L. bataviae showed still no conclusive result. Their antibody formation resembled that in most of human cases. Serum electrophoresis in human Leptospirosis bataviae revealed increased alpha-II and gamma globulin, not correlating with antibody titres. Microscopic clump formation showed no correlation with gamma globulin. Gamma globulin and some beta fraction showed leptospiral antibodies. One sided absorption test was tried in eight new isolates. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE