MOLECULAR NEUROCHEMISTRY OF THE HIPPOCAMPUS AND OTHER BRAIN SITES DURING CONDITIONED AVOIDANCE BEHAVIOR.
YORK UNIV TORONTO (ONTARIO) MOLECULAR PSYCHOBIOLOGY LAB
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Two experiments were conducted to evaluate neurochemical changes in the ventral hippocampus of rats in a one way active avoidance conditioning task. The dependent variables were amounts of RNA, DNA, and proteins ratios of these three the specific activity of protein and tissue pool fractions and the relative specific activity of the protein fraction. In these experiments a lower shock level was used than in previous experiments. The learning animals showed a tendency to greater specific activity of TCA and protein fractions and to a greater relative specific activity of the protein fraction in brain tissue than did non-learning animals. The results concerning individual brain tissues suggested that the medial ventral cortex, and possibly the posterior ventral cortex, may be involved in this type of learning. No significant differences were found in the ventral hippocampus. Author