PROBLEMS IN AERIAL APPLICATION: A COMPARISON OF THE ACUTE EFFECTS OF ENDRIN AND CARBON TETRACHLORIDE ON THE LIVERS OF RATS AND THE RESIDUAL EFFECTS ONE MONTH AFTER POISONING
FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST
Pagination or Media Count:
A comparison was made of the effects on the liver of carbon tetrachloride and of endrin. Rats poisoned with either endrin or carbon tetrachloride were studied in the acute stage and after a one month recovery period. With endrin, fat was deposited perilobularly in relatively fine droplets, RNA was diffuse perilobularly and was in clumps elsewhere and the density of the Weil stain was increased in acutely poisoned rats. By contrast, the fat was centrolobular in CC14 poisoned animals, there was little change in RNA except for its absence in necrotic cells and the density of the Weil stain was only slightly greater than in the controls. In the one month recovery period, all changes seen in the acute animals virtually disappeared and histologically the livers were almost normal.