AN IMMUNE SERUM AGAINST THE NORTH AMERICAN CORAL SNAKE (MICRURUS FULVIUS FULVIUS) VENOM OBTAINED BY PHOTOOXIDATIVE DETOXIFICATION.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Photooxidation of crude Micrurus fulvius fulvius venom by visible light in the presence of methylene blue resulted in the detoxification of this venom. Rabbits inoculated with the photooxidized venom produced an immunoglobulin which protected mice against many-fold lethal doses of the unaltered venom. Neither local nor systemic ill effects were observed in rabbits or mice. The effectual and harmless toxoid obtained could be used for active immunization, in suitable circumstances, as well as for production of antisera for passive immunization. Author