Accession Number:

AD0645081

Title:

A GENERALIZED HERPES VIRUS INFECTION IN OWL MONKEYS,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

Report Date:

1966-06-30

Pagination or Media Count:

30.0

Abstract:

The generalized viral disease caused by a herpes virus in owl monkeys Aotus trivirgatus is an acute fulminating disease that has been 100 fatal. The incubation period for all experimentally inoculated owl monkeys except the intracerebrally infected animal, which died in 3 days, ranged between 5 to 7 days and death occurred from 7 to 10 days after inoculation. Late in the course of the disease there is a moderate leukopenia that progresses to a terminal degenerative shift to the left this is accompanied by anisocytosis, poikilocytosis, nucleated erythrocytes, and a moderate decrease in hemoglobin and packed cell volume. The most significant clinical change is the 3- to 10-fold increase in both SGOT and SGPT values. Pathologic changes are severe and affect primarily the liver, oral mucosa, adrenals, lymphoid tissue and skin, though lesions have been observed in other tissues, including the brain and kidney. A similarity of lesions to those seen in generalized herpes simplex virus disease of humans is suggested. Author

Subject Categories:

  • Biology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE