TISSUE MONOAMINE OXIDASE INHIBITIONS BY CONVULSIGENIC DOSES OF HYDRAZINES AND RELATED B6-HYDRAZONES.
Progress rept. Sep 62-Aug 64,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
Pagination or Media Count:
Convulsigenic doses 0.42 to 1.68 mM.kg. of the pyridoxal hydrazone of unsymmetrical dimethylhydrazine UDMH I.P. produced from 13 to 32 inhibition of rat brain monoamine oxidase MAO. Administration of the hydrazones of monomethylhydrazine MMH and of hydrazine H produced mild to severe convulsions, but little or no tissue MAO inhibitions. Pyridoxal PAL plus UDMH I.P. led to more severe convulsions than caused by UDMH alone. MAO inhibitions also increased. In contrast, pyridoxine PIN plus UDMH I.P. prevented UDMH convulsions, and tissue MAO inhibitions were negligible. PAL markedly decreased the MAO inhibition activity of MMH in brain and liver tissues, but not the convulsigenic activity of MMH. PIN prevented MMH convulsions reducing liver, but not brain, MAO inhibitions due to MMH. There was no consistent relationship between MAO inhibitions and the convulsigenic properties of the hydrazines and hydrazones studied. Author