EFFECTS OF MAGNESIUM PEMOLINE ON SHOCK AVOIDANCE CONDITIONING AND ON MOLECULAR NEUROCHEMISTRY.
YORK UNIV TORONTO (ONTARIO) MOLECULAR PSYCHOBIOLOGY LAB
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Three experiments were conducted with rats in one way active avoidance conditioning apparatus to determine the effects of magnesium pemoline on this task and on brain neurochemistry. The dependent variables were number of avoidances, latency, and trial of first avoidance amounts of RNA, DNA, and proteins ratios of these three the specific activity of RNA, protein, and tissue pool fractions and the relative specific activity of the RNA and protein fractions. Rats fed magnesium pemoline showed enhanced conditioning a tendency to lower specific activity of the TCA, RNA, and protein fractions and a tendency to lower relative specific activity of the protein fraction. There was a suggestion that the medial and posterior ventral cortices may play an important role in this type of conditioning. Author