Accession Number:

AD0643091

Title:

DEVELOPMENT OF AN ORALLY EFFECTIVE INSECT REPELLENT

Descriptive Note:

Annual rept. 1 Nov 1965-31 Oct 1966

Corporate Author:

IIT RESEARCH INST CHICAGO IL

Personal Author(s):

Report Date:

1966-11-11

Pagination or Media Count:

99.0

Abstract:

Compounds were tested for mosquito repellency by the electronic recording method, and the results were statistically analyzed. A computer program was devised that yields a repellency index and confidence limits in comparison with controls for each test compound on the basis of data obtained from the electronic recordings. A hypothesis was developed that could explain the mechanism of attraction of mosquitoes to warm-blooded animals. They hypothesis states that gamma-aminobutyric acid GABA, a substance which is known to inhibit transmission of nerve impulses across certain synaptic junctions in some animal species, may also play an inhibitory role in the nervous system of mosquitoes. GABA was shown to reversibly combine with carbon dioxide CO2, depending upon temperature and CO2 tension, and it was proposed that the GABA-CO2 complex formed no longer possesses the synaptic inhibitory power of GABA alone. The interreactions of the GABA with CO2 and heat were hypothesized to form the basis of mosquitoes attraction to hosts.

Subject Categories:

  • Hygiene and Sanitation
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE