EVALUATION OF RADIOPROTECTIVE ACTIVITY OR PROPERTIES OF SELECTED CHEMICAL COMPOUNDS IN LARGE ANIMALS.
Annual progress rept., 1 Jul 65-1 Jul 66,
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
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The objective of the research was to investigate and evaluate the radioprotective activity and properties of selected chemical compounds in large animals, and to gain insights into their mechanism of action. With respect to chemical radioprotection efforts were directed toward three general areas a Studies on Compound WR-1607 in lethally X-irradiated dogs beagles as well as mongrels and the possibilities of combinations of other compounds with WR-1607 b The protective effect of small external lead cuffs, alone or in combination with chemicals, in dogs and c Studies on chemical radio-protection in mice, employing hemopoietic colony-forming units CFU as the endpoint. Author