PROPHYLAXIS AGAINST SARIN POISONING IN THE RAT BY ORAL ADMINISTRATION OF 2-PAMC1
Rept. for Nov 1959-Feb 1960
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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The aims of the present study were to a establish the parameters associated with oxime concentration in plasma following oral administration of 2-PAMC1 2-pyridine aldoxime methochloride to rats, b determine the combined effect of prophylaxis with 2-PAMC1 and treatment with atropine on the toxicity of sarin isopropyl methylphosphonofluoridate, GB in rats, and c establish a correlation between oxime level in plasma and protection afforded against sarin poisoning. It was concluded that 1 When 2-PAMC1 is administered orally to rats, the plasma oxime level rises rapidly, reaches a maximum after about 1 hr, and then decreases at a first-order rate. The biological half-life of 2-PAMC1 in the rat is estimated to be 1.4 hr. 2 A prophylactic effect of 2-PAMC1, when used in conjunction with atropine, has been demonstrated in rats poisoned with sarin. 3 The protection afforded by 2-PAMC1 against sarin poisoning in rats can be correlated with the oxime level in the plasma at the time of sarin poisoning.
- Chemical, Biological and Radiological Warfare