THE PERIPHERAL BLOOD CIRCULATION AND THE PERMEABILITY OF THE VESSEL WALLS IN THE DYNAMICS OF EXPERIMENTAL PLAGUE
ARMY BIOLOGICAL LABS FREDERICK MD
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During experimental plague in guinea pigs a slowing down is observed in the absorption of radioactive phosphorus from the subcellular tissue, progressing with the course of the infectious process. The sharp reduction in the intensity of resorption of the subcutaneously administered radioactive phosphorus testifies to the significant disruptions in the functions of the capillary system during plague in guinea pigs. In the course of plague infection in guinea pigs a decrease is observed in the rate of the blood flow, which in the last days of the infectious process is decreased by almost 2 times in comparison with the initial rate noted prior to infection. During experimental plague infection a disruption is noted in the permeability of the vascular wall and as a result of this the discharge of plasma into the intertissue spaces takes place. The complex of pathological changes with the disruption of the rate of blood flow, intensity of absorption of substances, the degree of permeability of capillary membranes and the discharge of plasma from the vascular channel into the tissues, plays an important role in the overall chain of functional disruptions which set in the organism of a guinea pig during plague infection.
- Medicine and Medical Research