A METHOD OF DETERMINING SENSITIVITY OF RICKETTSIA BURNETI TO ANTIBIOTICS IN VITRO
ARMY BIOLOGICAL LABS FREDERICK MD
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A method was suggested for determining the activity of antibiotics with respect to Rickettsia Burneti in vitro in cells of chicken fibroblasts. The activity of the antibiotics is determined from the difference in the amount of cells intently affected by Rickettsia in the control culture and in the culture undergoing the action of antibiotics. The effect of antibiotics is manifest in a sizable reduction of the propagation of Rickettsia Burneti in the cytoplasm of fibroblasts, a reduction in number of Rickettsia-affected cells, and in the elimination of the cytopathogenic effect of Rickettsia on cells of tissue cultures.