Accession Number:

AD0641752

Title:

A METHOD OF DETERMINING SENSITIVITY OF RICKETTSIA BURNETI TO ANTIBIOTICS IN VITRO

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1964-08-01

Pagination or Media Count:

11.0

Abstract:

A method was suggested for determining the activity of antibiotics with respect to Rickettsia Burneti in vitro in cells of chicken fibroblasts. The activity of the antibiotics is determined from the difference in the amount of cells intently affected by Rickettsia in the control culture and in the culture undergoing the action of antibiotics. The effect of antibiotics is manifest in a sizable reduction of the propagation of Rickettsia Burneti in the cytoplasm of fibroblasts, a reduction in number of Rickettsia-affected cells, and in the elimination of the cytopathogenic effect of Rickettsia on cells of tissue cultures.

Subject Categories:

  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE