EFFECT OF DIFFERENT INERT GASES AND LOW PRESSURE NORMOXIC ENVIRONMENTS ON OXYGEN UPTAKE IN MICE.
Final rept., Nov 64-Jan 66,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
Pagination or Media Count:
Exposure of adult male Swiss albino mice to air at 28C., ground level pressure, for 24 hours resulted in an oxygen uptake of 78.0 ml.hr. STPD as compared with 77.4 ml.hr. in 100 oxygen, 77.7 ml.hr. in 80 Ar20 O2, and 84.2 ml.hr. in 80 He20 O2. The increase in oxygen consumption in HeO2 at this temperature approached significance P .10. With another group of mice, oxygen consumption during 3-hour exposures to 80 He20 O2 at 32C. was 88.5 ml.hr. as compared with 90.2 ml.hr. in air. These differences were not significant. With a third group of mice, exposure to 100 oxygen at 226 mm. Hg absolute at 28C. for 3 hours resulted in an oxygen consumption of 89.7 mlhr. as compared with 88.8 ml.hr. in air at ground level pressure. Differences again were not significant. It was concluded that the metabolic stimulating effect of helium at 28C. was a result of its high thermal conductivity, and at 32C. skin temperature this effect was no longer apparent. Changes in barometric pressure had no effect on oxygen consumption. Author
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