VIRAL ANTIBODY PRODUCTION IN ANIMALS EXPOSED TO A SPACE CABIN ENVIRONMENT.
Progress rept. Jul-Sep 65,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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Synthesis of antibody against vaccinia virus was investigated in rabbits exposed to a simulated space cabin environment. The atmospheric pressure in the cabin was equivalent to an altitude of 18,000 feet the partial pressure of oxygen was approximately that of sea level. The animals were acclimatized for 7 days and then immunized with a series of injections of purified vaccinia virus over a period of 5 weeks. Control animals remained at ground level and received identical injections from the same virus pool. Specific antibody produced by each group was tested for its neutralization titer and distribution of specific activity in fractions separated by column chromatography and sucrose gradients. No qualitative or quantitative differences in antibody produced were noted. Author
- Medicine and Medical Research
- Stress Physiology