Accession Number:

AD0641427

Title:

EFFECT OF PLAGUE TOXIN ON BLOOD PROTEINS AND INCORPORATION OF METHIONINE-S35 INTO TISSUE PROTEINS,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Domaradskii,I. V.
• Klimova,I. M.
• Tokareva,A. A.

Report Date:

1965-12-01

Pagination or Media Count:

13.0

Abstract:

In white mice plague microbe toxin disrupts the ratio between the protein fractions of the blood serum. There is a decrease in the content of albumins and an increase in the concentration of globulins. However, it is difficult to say due to which fraction of globulins the lowering of the albumin-globulin coefficient takes place. The stated changes have a stable nature and are detected in surviving animals even after 3 days following the administration of toxin to them. During plague intoxication the total amount of protein is not changed. The influence of the toxin on the blood serum proteins of guinea pigs is doubtful. Plague intoxication changes the rate of incorporation of Methionine-S35 into the blood proteins of white mice and does not influence the rate of incorporation of methionine-S35 into the blood proteins of guinea pigs and the tissue proteins of both species of animals. Author

Descriptors:

• *YERSINIA PESTIS
• BIOSYNTHESIS
• TOXINS AND ANTITOXINS
• BLOOD PROTEINS
• MICE
• GUINEA PIGS
• SERUM ALBUMIN
• TOXICITY
• BLOOD SERUM
• METHIONINE
• DOSAGE
• USSR

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE