Accession Number:

AD0641121

Title:

IN VIVO DEGRADATION OF RADIOACTIVE C14 BUTYL CYANOACRYLATES IN RATS (30 DAYS).

Descriptive Note:

Technical rept.,

Corporate Author:

WALTER REED ARMY MEDICAL CENTER WASHINGTON D C ARMY MEDICAL BIOMECHANICAL RESEARCH LAB

Personal Author(s):

• Pani,K. C.
• Gladieux,Gary
• Lange,Harold

Report Date:

1966-08-01

Pagination or Media Count:

10.0

Abstract:

N-Butyl-2-cyanoacrylate is another of the family of cyanoacrylate tissue adhesives. It has proven to be as good an adhesive as methyl-2-cyanoacrylate, but much less histotoxic. It is known that methyl-2-cyano-acrylate is completely degraded in the rat and excreted via the urine, feces, and probably the lungs. This study is designed to investigate the manner and extent to which butyl-2-cyanoacrylate is degraded and excreted from rat implant sites. Author

Descriptors:

• (*ADHESIVES
• METABOLISM)
• (*SURGICAL IMPLANTATION
• DEGRADATION)
• (*ACRYLIC RESINS
• METABOLISM)
• (*NITRILES
• METABOLISM)
• TRACER STUDIES
• IN VIVO ANALYSIS
• EXCRETION
• RADIOACTIVE ISOTOPES
• ESTERS
• TISSUES(BIOLOGY)

Subject Categories:

• Anatomy and Physiology
• Medical Facilities, Equipment and Supplies
• Adhesives, Seals and Binders

Distribution Statement:

APPROVED FOR PUBLIC RELEASE