EPIDEMIOLOGICAL AND GENETICAL STUDIES ON THE DRUG-RESISTANCE OF SHIGELLAE AND STAPHYLOCOCCI.
Final rept. no. 4, Jun 65-Jun 66,
INSTITUTE OF MICROBIAL CHEMISTRY TOKYO (JAPAN)
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The surveys for the staphylococcal strains, isolated from clinical sources, enclosed the following facts 1 With reference to four drugs tetracycline TC, streptomycin SM, penicillin G PC, and sulfanilamide SA, multiple resistant strains were manifest and they were restricted to specific phage group. 2 It was notified that there are maximum population of resistant strains to some drug in the restricted area, termed as M.P.R. 3 It was found that there are two types of resistant strains the one becomes resistant easily and multiply when new drug is introduced, the other stays single SA or double PC. SA, SM. SA resistant. 4 The resistance to TC was easily transduced in high frequencies with the prophages obtained from multiple resistant strains. The resistance to SA and SM was jointly transduced with TC, and vice versa. By contrast, the resistance to PC, i.e., an ability of penicillinase PCase formation have never been transduced together with the resistance to TC, SM, and SA. 5 The resistance to macrolide antibiotics Mac EM, OM, LM, SP is eliminated together and irreversively by treatment with acriflavine or by ultraviolet irradiation, and is transduced jointly with phages. From these results, it was concluded that Mac resistance is located on a plasmid, which exists extrachromosomally. 6 It was concluded that gene which governs the formation of PCase is located on a plasmid. Two types of plasmids were found the one is Mac. PCase and the other PCase. Author