Accession Number:

AD0640316

Title:

THE RESPONSE OF ERYTHROPOIETIC STEM CELLS OF MICE TO IRRADIATION WITH FISSION NEUTRONS,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1966-08-19

Pagination or Media Count:

31.0

Abstract:

The destruction of erythropoietic stem cells by irradiation with fission neutrons was studied in plethoric C57 leaden male mice by measuring the incorporation of Fe59 into erythrocytes 48 hours after a dose of erythropoietin. The survival of stem cells in mice exposed to single doses of neutrons at 37 radmin. followed the single-hit multi-target model of radiation injury to cells. D is dose, D sub o is 37 dose, and E is target multiplicity. D sub o was a constant, equal to 27.8 rads for all animals, but E varied from 1 to 4 in different animals. The survival of stem cells in mice exposed to single doses of neutrons at 1.75 radmin. followed the single-hit multi-target model, with D sub o 26 rad, for those animals for which E 1, but animals with E1 did not fit the model. The survival of stem cells in mice exposed to 3 doses at 37 radmin. at intervals of 10-12 hours also followed the single-hit multi-target model, with mean D sub o 26 rad, and a distribution of values of E similar to that in the single dose. The data strongly imply that the loss of stem cells follows the multi-target model, but that E. instead of being a constant, is a basic biological variable of the response. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE