FORMATION OF METHYLENE BRIDGES IN THE REACTION OF RIBONUCLEIC ACID WITH FORMALDEHYDE
ARMY BIOLOGICAL LABS FREDERICK MD
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From RNA, processed with formaldehyde, a product of the condensation of adenosine with formaldehyde was isolated. It was identified by chromatographic mobility and UV spectrum as methylene-bis-adenosine. In the alkaline hydrolyzate of RNA, treated with C14H2O, C14-methylene-bis-adenylic acid was detected chromatographically. Thus, experimental confirmation was obtained of the earlier expressed supposition concerning the formation of methylene bridges in the reaction of RNA with formaldehyde.