HUMORAL CONTROL OF THE ERYTHROPOIESIS DURING ALTITUDE CHANGES.
Annual rept. no. 1, May 65-Apr 66,
INSTITUTO DE BIOLOGIA ANDINA LIMA (PERU)
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A study was made of humoral control of erythropoietic activity in men during and after altitude exposure. Plasma from sea level subjects after 8, 24 and 48 hours of exposure to 4,450 meters of altitude produced a gradual increase of erythropoietic activity in starved rats. Urinary extracts had the same effect in samples obtained after 24 and 48 hours. No increase of erythropoietic activity was observed in plasma or urinary extracts from altitude natives when injected to rats. A depressing effect of plasma filtrate from altitude natives after 9 days of residence at sea level had a depressory effect on erythropoiesis in rats exposed to 18,000 feet. No changes of erythropoietic activity were observed when urinary extracts of natives of altitude were injected into starved rats after several periods of time at sea level. Additional observation in the urinary extracts from aplastic patients showed a very high degree of erythropoietic activity which diminished in patients successfully treated with anabolic steroid meta-androstenolona. Author
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