Accession Number:

AD0639455

Title:

MODE OF ACTION OF AN INHIBITOR FROM AGAR ON GROWTH AND HEMAGGLUTINATION OF GROUP A ARBOVIRUSES

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1965-04-02

Pagination or Media Count:

9.0

Abstract:

A polysaccharide obtained from agar, and having properties similar to a previously described sulfated polysaccharide, was observed to inhibit growth and hemagglutination of some group A arboviruses. The evidence presented confirms that the inhibitory activity, in part, is the result of direct interaction between the agar polysaccharide AP and free virus particles. Additional evidence indicates that inhibition of viral growth also occurs as the result of interaction between AP and the chick-fibroblast cells used for propagation of the virus. The possibility was considered, therefore, that at least two different inhibitors could be present in AP-one that reacts directly with the virus particle and another that reacts with host cells. AP does not induce the production of interferon in the test system used.

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE