THE SIGNIFICANCE OF TYPE E BOTULINUM TOXIN ACTIVATION IN THE LABORATORY DIAGNOSIS OF BOTULISM
ARMY BIOLOGICAL LABS FREDERICK MD
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Conclusions On artificial nutrient media, Cl. botulinum produces a toxin and a nontoxic prototoxin. The latter may be transformed into a toxin due to the action of various enzymes pancreatin, proteinase of Cl. sporogenes. when botulinum prototoxin type E reaches the digestive tract its activation by enzymes takes place. As a result of this the toxic effect on the organism is strengthened. During the investigation of various materials food products, discharges from a patient, section material, original seedings for the presence of botulinum toxins, it is necessary to subject the nontoxic filtrates to activation by pancreatin, and after this set up biological tests and the neutralization reaction with antibotulinum serum type E.