A STUDY OF THE BIOLOGICAL ESSENCE OF THE VIRULENTPROPERTIES OF MICROBES. REPORT II. THE NATURE OF PNEUMOCOCCUS INFECTION IN WHITE MICE DEPENDING ON THE ROUTE OF INFECTION AND THE DOSE OF CAUSATIVE AGENT
ARMY BIOLOGICAL LABS FREDERICK MD
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Following the infection of mice with pneumococci the following gradation in the decrease of sensitivity of the animals was established depending on the route of introduction of the microbes Intraperitoneal injection, infection in the extremity, in the vein, and by the intranasal route. Under specific conditions infection with small doses in the extremity or infection following the use of moderate penicillin therapy it is possible to observe a rapidly passing and weakly expressed bacteremia. The animals in which bacteremia was detected remained alive in a great number of cases. The temporary and scanty bacteremia following infection of mice in the extremity, and also the symptomless process following the intranasal infection of animals, caused a profound immunological reorganization in them, as a result of which the mice became highly resistant to pneumococcus infection. This immunological response was not accompanied by the formation of specific agglutinins.
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