THE SEQUESTRATION OF ERYTHROCYTES IN IRRADIATED DOGS.
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
Pagination or Media Count:
Fifteen dogs received 200 R of X-ray exposure. Twenty-four hours following irradiation they were injected with both free Fe55 and Fe59- labeled red cells which had been heat damaged. Fe55 measurements indicated a significantly decreased plasma clearance and red cell incorporation of iron indicating decreased erythropoiesis as a result of X-ray exposure. Sequestration of heat damaged red cells by the reticulo-endothelial system was decreased in the irradiated dogs compared to non-irradiated controls. The explanation given is that at relatively low exposures to irradiation, endogenous cellular debris imposes a blockage of the RES so that only small amounts of injected particles produce a noticeable delay in clearance. No difference in plasma iron turnover could be detected between irradiated and control dogs. It is suggested that iron turnover is an unreliable measure of erythropoiesis. Author