EFFECTS OF REPRESENTATIVE ANTICHOLINERGIC AND ANTICHOLINESTERASE DRUGS ON HUMAN LEARNING AND RETENTION.
EDGEWOOD ARSENAL MD
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The effects of an anticholinergic drug scopolamine and an anticholinesterase drug physostigmine upon human learning and retention were investigated. Six groups of 10 subjects each were randomly assigned to six different drug-dose conditions--a saline placebo, two different doses of scopolamine, and three different doses of physostigmine. The data were collected over a series of ten 2-day experimental sequences, each composed of a familiarization phase, an acquisition phase, and a retention phase. Within each phase, the subjects performed three experimental tasks--pursuit rotor tracking, verbal learning of three-letter words, and memory-for-faces. Analyses of variance of the data from the acquisition and retention phases indicated that there were no significant differences in performance on any of the three experimental tasks among the six-drug-dose conditions. Author