COMPARISON OF THE EFFECTS OF DIETHYL ETHER, CHLOROFORM, AND HALOTHANE ON THE ISOLATED RAT LIVER PREPARATION.
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
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The effects of ether, chloroform, and halothane at anesthetic levels were studied in the isolated perfused rat liver preparation to minimize possible neurogenic factors in the production of liver injury from these agents and to facilitate investigation of early biochemical and physiological reponses. Generally similar effects produced by all three anesthetic agents were reduction in O2 uptake, decrease in bile secretion, increase in perfusate glucose, and a decrease in blood pH. The order of relative potency in eliciting a standardized response in each of these parameters was highly variable, but characteristically, it was chloroform halothane diethyl ether. A qualitative difference between diethyl ether and the two halogenated hydrocarbons was the production of vasoconstriction by the former, vasodilatation by the two latter. The administration of dihydroergotamine before halothane infusion eliminates the glycogenolytic effect, greatly diminishes the reduction in oxygen uptake rate, but has no measureable effect upon the decrease in vascular resistance characteristic of halothane. Author