A STUDY OF THE DYNAMICS OF THE BACTERIOLOGICAL PROCESS DURING TREATMENT OF EXPERIMENTAL TULAREMIA WITH KANAMYCIN, CHLORTETRACYCLINE AND STREPTOMYCIN
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
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Guinea pigs infected with lethal doses of tularemia bacteria displayed a marked decrease in number of bacteria in organs and tissues after administration of Kanamycin, chlortetracycline or streptomycin was begun at the height of the fever, about the fourth day. After the 10-day treatment was discontinued most animals were found free of bacteria however, some suffered recurrence with some increase in number of bacteria in the organs. Kanamycin and streptomycin yielded best results. Chlortetracycline treatment was more difficult and less effective because of the insufficient dosage and treatment time used because of its toxicity for guinea pigs.