Accession Number:

AD0637265

Title:

PROCEEDINGS OF A CONFERENCE ON BOTULINUM TOXIN 28 AND 29 JUNE 1965

Descriptive Note:

Special publication

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1966-07-01

Pagination or Media Count:

272.0

Abstract:

Twenty monographs were presented at a conference on botulinum toxin. Each presentation was followed by a discussion period. Data in the following fields of research were presented 1 pharmacological aspects, 2 relation to body weight, 3 dissociation of Type A toxin, 4 lethal subunits of Type A toxin, 5 availability of toxin forms, 6 important research questions, 7 possible absorption and distribution sites, 8 localization with lead binding at motor end plates, 9 isolation of muscle-tissue activity, 10 fractionation and fluorescent labeling, 11 atrophy in chick muscles after massive doses, 12 photodynamic treatment, 13 pharmacodynamics, 14 clinicalpathological studies in monkeys, 15 the use of latex agglutination as a test technique, 16 results of IIT experiments, 17 production of human antibotulism serum, 18 lung absorption of high molecular weight molecules, 19 choline-C14 and acetylcholine C14 distribution, and 20 central and peripheral effects of Type A toxin. The basis for these studies was a close evaluation of the mechanism of action of the toxin, its effect on tissues, and an improvement in diagnostic and therapeutic techniques.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE