STUDIES ON CHEMOTHERAPY AND SERODIAGNOSIS FOR CLONORCHIS SINENSIS INFECTION.
CHIBA UNIV (JAPAN) DEPT OF PARASITOLOGY
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The authors conducted the first use of this drug for the treatment of clonorchiasis patients after confirming the satisfactory results in the animal experiments. Eight inpatients with clonorchiasis in the hospital were treated as the first human cases to receive 1, 4-bis-trichloromethylbenzol Hetol. A daily dose of 100 mgkg of Hetol was administered every other day for 5 doses in all. For one year after the completion of the treatment fecal examinations with centrifugation technique were periodically carried out. On the lapse of 3 to 5 weeks after the treatment, the feces became negative for Clonorchis eggs in all of the 8 cases and 7 cases except one case have since been continuing negative for eggs. Elaborated examinations for side effects due to Hetol revealed nothing abnormal in liver function test, urinalysis and in other respects. The results thus far described have led to conclusion that Hetol is safe to use for human clonorchiasis and is more effective than the conventionally used drugs. Author
- Anatomy and Physiology
- Medicine and Medical Research