SECRETORY RESPONSES OF EXTRAMEDULLARY CHROMAFFIN TISSUE.
AGRICULTURAL RESEARCH COUNCIL BABRAHAM (ENGLAND) INST OF ANIMAL PHYSIOLOGY
Pagination or Media Count:
When the isolated inferior mesenteric ganglion of the dog was perfused with Locke solution, the effluent contained noradrenaline and adrenaline. At rest the amount of noradrenaline released ranged from 0.7 to 40 ngmin, that of adrenaline from 0.7 to 25 ngmin. Electrical stimulation of the inferior splanchnic nerves did not alter the catecholamine content of the perfusate, and stimulation of the ascending mesenteric nerves caused an increase to little more than twice the resting value. When acetylcholine and dimethylphenylpiperazinium iodide were infused into the preparation, the catecholamine content of the effluent rose to an amount ranging from 6 to 100 times the resting level. Two drugs with muscarinic action pilocarpine and N-benzyl-3-pyrrolidyl acetate methobromide produced only a very small stimulation of catecholamine releasen. Angiotensin, in doses ranging from 20 ng to 2 micrograms, inhibited release of catecholamines, and bradykinin had a weak stimulatory effect. It is suggested that the catecholamines released into the effluent were derived from chromaffin tissue in the ganglion evidence for innervation of this tissue was unobtainable, but its catecholamines were readily released by the injection of nicotinic substances. Author
- Anatomy and Physiology