PATHOGENESIS OF A MYCOPLASM INFECTION IN SWINCE.
Final rept., 1962-1964.
AEROSPACE MEDICAL RESEARCH LABS WRIGHT-PATTERSON AFB OHIO
Pagination or Media Count:
A Texas isolate of Mycoplasma hyoarthrinosa was injected into Hampshire and Yorkshire pigs weighing 40 and 100 pounds. Pathologic lesions in all 40-pound pigs were absent or minimal. Hampshire pigs that were not deprived of colostrum at birth had the greatest response to the injected organism. Colostrum-deprived Hampshirepigs weighing 100 pounds elicited a response similar to Yorkshires that had not received colostrum at birth. An indirect hemagglutination plate test was used to monitor the serological response of these pigs to M. hyoarthrinosa. The serological response varied from none in several pigs to a titer of 1640 in one 100-pound Hampshire pig 9 days postinoculation. The indirect fluorescent antibody technique was applied to the demonstration of M. hyoarthrinosa in swine tissues. Demonstration of the organism was accomplished and provided positive evidence that the organism can be present in joint cavities in the absence of microscopic lesions in adjacent tissues. When the organism invaded the synovial tissue, it elicited a cellular response. In young pigs weighing 100 pounds or less the Mycoplasma was isolated from joint fluids of clinically normal and histopathogically normal joints. When the organisms invaded the synovial tissues of pigs weighing 100 pounds or more, microscopic and gross lesions were produced. The poor antigenicity of this class of organism and the onset of immunologic maturity are important factors in the development of lesions in these animals. Author
- Animal Husbandry and Veterinary Medicine