Accession Number:

AD0633368

Title:

STAPHYLOCOCCAL ENTEROTOXIN GASTROENTERITIS IN RHESUS MONKEYS

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s):

Report Date:

1965-10-11

Pagination or Media Count:

21.0

Abstract:

Intragastric administration of purified staphylococcal enterotoxin B in rhesus monkeys produced an acute gastroenteritis which was well developed by 2 hours, reached a maximum at 4 to 8 hours and rapidly regressed to a state approaching normal by 72 hours. Gastritis was most severe in the antral and fundic mucosa and was less severe in the area of the stomach containing parietal cells. The lesion in the small intestine was of decreasing severity from jejunum to ileum. In the jejunum there was severe epithelial damage with distended villi and crypts extending nearly to the surface. The ileum exhibited much less epithelial damage and only mild alteration in villus architecture. After daily intragastric doses of enterotoxin 6 of 15 monkeys developed severe antral gastritis and superficial gastritis with focal deep extension in the gastric body mucosa. About one-third of the monkeys given daily doses of enterotoxin had a mild enteritis characterized by crypt lengthening and a slight increase in inflammatory cell infiltration. Author

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE