CELL PROLIFERATION KINETICS IN THE TONGUE AND INTESTINAL EPITHELIA OF HIBERNATING DORMICE (GLIS GLIS).
Interim technical rept. 5 Jan-1 Oct 65,
HARVARD UNIV BOSTON MASS DEPT OF ANATOMY
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The investigation attempts to define the state of cellular division in epithelial populations of the hibernating dormouse Glis glis and to describe the dynamics of the cells response to arousal. It was found that during hibernation DNA synthesis occurs at a markedly reduced rate, but the number of epithelial cells synthesizing DNA is the same in both hibernating and active animals. Labeled mitotic figures are not seen for up to 96 hours of continuous hibernation after tritiated thymidine is administered, suggesting there is a block in G2. In hibernation the mitotic index drops and no anaphases or telophases are seen, suggesting presence of an intermitotic block. When animals are aroused, there is a flourishing of mitoses with appearance of anaphases, telophases and labeled mitotic figures indicating that both blocks have been relieved with a partial synchronization of proliferating cells. Author
- Anatomy and Physiology