VIABILITY OF ADULT RAT SKIN FOLLOWING 13 MEV PROTON IRRADIATION.
TEXAS A AND M UNIV COLLEGE STATION
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The effects of low energy 13 Mev protons upon adult rat skin were studied. The study was conducted in three parts. 1 A pathologic study was conducted in which the carcinogenesis of proton irradiation was determined eight months postirradiation. Thirteen groups of ten rats each, which had been irradiated at progressively increasing doses per group at increments of 100 rad per group were examined in order that a dose-pathology relationship might be established. 2 A series of pilot experiments were performed to develop a cell culture technique conducive to growth of adult skin cells and to differentiate between the behavior in culture of irradiated cells as opposed to the behavior of nonirradiated cells. 3 A series of experiments were conducted using cells in culture as a method to detect the point in time postirradiation in which irradiated skin cells become carcinomatous. The conclusions from this limited study point out that cell culture techniques may offer a method to detect developing carcinoma cells before neoplastic lesions actually become observable. Author