EFFECTS OF HYDRAZINE ON BLOOD GLUCOSE AND MUSCLE AND LIVER GLYCOGEN IN THE ANESTHETIZED DOG.
Progress rept., Mar-Nov 64,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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Intravenous injection of diluted hydrazine 25 mg.kg. into anesthetized dogs caused prompt elevation of blood glucose levels, which reached a maximum in about 2 hours and decreased progressively during 4 hours thereafter. Liver glycogen levels fell rapidly during the first 4 hours after injection of hydrazine. Depletion of liver glycogen stores was associated with severe hypoglycemia and some depletion of muscle glycogen. Packed cell volume progressively increased after hydrazine administration. Microscopic examination of liver tissue from treated dogs showed swelling of hepatic cells and apparent fatty infiltration. Sections of liver stained with PAS confirmed the rapid glycogen depletion. It is postulated that hydrazine affects the carbohydrate concentration of various tissues by a primary insult to the glycogenetic-glycogenolytic mechanism of the liver. Author