Accession Number:

AD0632894

Title:

BIOCHEMICAL AND PHYSIOLOGICAL FACTORS OF THE IMMUNE RESPONSE

Descriptive Note:

Annual progress rept., 1 May 1965-30 Apr 1966

Corporate Author:

NATIONAL JEWISH HOSPITAL DENVER CO DEPT OF EXPERIMENTAL IMMUNOLOGY

Report Date:

1966-06-01

Pagination or Media Count:

4.0

Abstract:

Antibody formation in adrenalectomized rabbits at high altitude is under study. A group of rabbits were acclimatized for 30 days to 10,600 feet at Echo Lake, then bilaterally adrenalectomized. A control group of adrenalectomized rabbits was maintained in Denver. After four weeks of recuperation both groups were given a primary i.v. immunization with bovine serum albumin BSA. Seven weeks later a secondary immunization with BSA was given. Serum samples were obtained at appropriate intervals and analyzed for precipitating antibody. High-altitude adapted and adrenalectomized rabbits exhibit a depressed primary immune response which reaches maximum titers later than high-altitude controls the time sequence of the secondary response is similar to controls but the titers achieved are lower.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE