BIOCHEMICAL AND PHYSIOLOGICAL FACTORS OF THE IMMUNE RESPONSE
Annual progress rept., 1 May 1965-30 Apr 1966
NATIONAL JEWISH HOSPITAL DENVER CO DEPT OF EXPERIMENTAL IMMUNOLOGY
Pagination or Media Count:
Antibody formation in adrenalectomized rabbits at high altitude is under study. A group of rabbits were acclimatized for 30 days to 10,600 feet at Echo Lake, then bilaterally adrenalectomized. A control group of adrenalectomized rabbits was maintained in Denver. After four weeks of recuperation both groups were given a primary i.v. immunization with bovine serum albumin BSA. Seven weeks later a secondary immunization with BSA was given. Serum samples were obtained at appropriate intervals and analyzed for precipitating antibody. High-altitude adapted and adrenalectomized rabbits exhibit a depressed primary immune response which reaches maximum titers later than high-altitude controls the time sequence of the secondary response is similar to controls but the titers achieved are lower.
- Medicine and Medical Research