CAROTENOID BIOSYNTHESIS IN PHOTO-SYNTHETIC BACTERIA AND HIGHER PLANTS.
Final scientific rept., 1 Sep 63-30 Aug 65,
EDWARD DAVIES CHEMICAL LAB UNIV COLL OF WALES ABERYSTWYTH
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Investigation on the biosynthesis of plant sterols are described. A number of possible phytosterol precursors were identified in peas and larch and include squalene, cycloartenol, 24-methylene cycloartenol, 24-methylene lophenol. The incorporation of 2-14C mevalonic acid into these various compounds was demonstrated whilst the incorporation of methyl-14C-methionine was observed into those steroids which contain an extra alkyl group at C24 of the steroid side chain. Using mevalonic acid and methionine doubly labelled with 14C and tritium studies were made regarding the mechanism of alkylation of the phytosterol side chain. Author