DURATION OF PASSIVE IMMUNITY TO BOTULINUM TOXIN OFFERED BY ANTITOXIN IN MICE AND RABBITS
Rept. for Sep-Dec 1963
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
Pagination or Media Count:
Various doses of botulinum antitoxin, types A and B, were administered to mice and rabbits by the intraperitoneal and intravenous routes. The persistence of a passive immunity to the type A toxin was determined by 1 administering challenge doses of the toxin at various times after the antitoxin and 2 determining the median lethal ratios LR50s of toxinantitoxin MUu that produced a 50 mortality rate at each challenge time. Decreases in LR50 with time reflect the fall in amount of antitoxin in the blood of the animals and decreased passive immunity to the toxin. A graph prepared from the data represents a mathematical model of mortality frequency distribution in mice and rabbits after 500 MU of toxin. Passive immunity declines steadily with time however, a sufficiently large dose of antitoxin in mice can produce passive immunity lasting for at least 49 days.
- Medicine and Medical Research