PRECIPITIN RESPONSE TO HUMAN SERUM BY A RABBIT POPULATION. COMPARISON OF STRESSES ON SECONDARY PRECIPITIN RESPONSES.
Rept. for May 61-Jun 64,
SASKATCHEWAN UNIV SASKATOON DEPT OF PHYSIOLOGY AND PHARMACOLOGY
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The report analyzes the secondary precipitin response of a population of rabbits subjected to various stresses and stress combinations. As administered in this experiment, the following stresses and stress combinations produced a statistically significant depression of precipitin production compared to controls during the anamnestic response of rabbits to a complex antigen human serum. These are rank-ordered with the stress producing the greatest effect at the head of the list 6-mercaptopurine 800 r whole-body gamma radiation immediately followed by 10 days at a simulated altitude of 15,000 ft. splenectomy followed 21 days later by 800 r of gamma radiation 800 r whole-body gamma radiation or 15,000-ft. simulated altitude for 10 days followed by 800 r whole-body gamma radiation and splenectomy. The following stresses showed no significant effect 15,000-ft. simulated altitude during the induction period 15,000-ft. simulated altitude for 10 days before the induction period major surgery involving implantation of dosimeters. Whole-body gamma radiation 800 r immediately followed by 15,000-ft. simulated altitude resulted in a mortality of 58 within the first 48 hours of decreased atmospheric pressure. Altitude exposure before 800 r gamma radiation did not indicate any synergism or antagonism related to the anamnestic response. Stress did not appear to increase antibody levels in the absence of a booster injection. Author
- Medicine and Medical Research