NATURE OF IMMUNE TOLERANCE BY MEANS OF SYNTHETIC POLYPEPTIDE ANTIGENS.
Rept. for 1 Nov 64-31 Oct 65,
WEIZMANN INST OF SCIENCE REHOVOTH (ISRAEL)
Pagination or Media Count:
Investigations were made of the immune response to protein carriers and polypeptidyl proteins in rabbits made tolerant to polypeptidyl proteins. Partial tolerance to poly-DL-alanyl determinants can be induced in rabbits injected at birth with one poly-DL-alanyl protein and then challenged with a conjugate of the same determinant with a different carrier. For studies of tolerance in rabbits, rabbit serum albumin behaved differently from heterologous carriers. The specificity of tolerance is not identical with the serological specificity of an antigen. This was concluded from studies in which, in order to clarify the role of the carrier in the specificity of tolerance, rabbits were made tolerant to polyalanyl RNase, polyalanyl HSA and polytyrosyl HSA. When the carrier proteins were injected into the tolerant animals, most of them remained tolerant to the protein carrier, even though the enrichment of the proteins with the polypeptidyl determinants was very extensive. The immune response in guinea pigs to linear and multichain copolymers of two, three or four different amino acids including tyrosine, glutamic acid, alanine and lysine, was studied.
- Medicine and Medical Research